Also, research suggests that BNZ-1 receptors affect sedation and anti-anxiety, while the BNZ-2 affects muscle relaxation, anticonvulsant activity, memory, and motor coordination. Studies in mice suggest that the alpha-1 subunit mediates sedation, amnesia, and ataxic effects of benzodiazepines, and alpha-2 and alpha-3 subunits mediate anxiolytic and muscle-relaxing effects of benzodiazepines. The benzodiazepine binding site is between the alpha-1 and gamma-2 subunits. A common GABA-A receptor in the CNS is comprised of two alpha-1 subunits, two beta-2 subunits, and one gamma-2 subunit. This receptor is comprised of five subunits, e.g., alpha, beta, gamma, delta, epsilon, rho, etc. Benzodiazepines bind to the GABA-A receptor. Alprazolam belongs to a class of psychoactive medications called benzodiazepines.
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